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Abstract In this review, we synthesize recent conceptual and experimental advances in neuroscience, highlighting selected studies that delineate the roles of reactive microglia and astrocytes in the contexts of developmental inflammatory stress, neurodegenerative diseases, and cellular senescence

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The arrows show vacuolization in the myelin sheath, the arrowheads indicate Schwann cells, and asterisks indicate myelin sheath disarrangement in the nerve fibers